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KMID : 0385520110240050360
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Analytical Science & Technology
2011 Volume.24 No. 5 p.360 ~ p.367
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Measurement of optical purity for commercial naproxen by chiral HPLC
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Yu Jeong-Jae
Lee Won-doo
Ryoo Jae-Jeong
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Abstract
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Optical purities of 10 commercialized naproxens prepared from eight Korean drug companies were examined by an optimized chiral HPLC condition. The Chiralcel OD-H column and ChiralHyun-LE(S)-1 column were used as chiral stationary phases and the mixed eluent of hexane/isopropanol/acetic acid as 100:2.85:0.1 was used as a mobile phase for effective enantioseparation. Optical purity values of most samples were higher than 97 percents, only one of them was about 95 percents. The average relative standard deviation of them appeared very small (0.034%).
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KEYWORD
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chiral chromatography, optical purity, commerical naproxen
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